I tried every over the counter eye drops, plus a few very expensive RX ones with very little relief! For a few years Restasis helped. Then I got Blethoraspams, which added to my problems! My eye doctor put me on blood serum eye drops, which are made from my own blood! No preservatives and nothing to be allergic to! They are the only eye drops that actually work for my dry eyes! They are expensive and you have to have a pharmacy that can compound them, but they are worth every penny! My eye doctor sent me to a Neurologist to get Botox shots around my eyes for the Blethoraspams, which help a lot. I've had to change some things in my lifestyle to keep from setting off the spasms. Being outside in bright sunshine or breeze will set them off. So I have to wear very dark wrap around sun glasses. Same with driving. Can't have air vents blowing on me. (Which is a real bitch living in Texas in the summer!) I had to quit wearing make up, especially on my eyes and be careful which creams and soaps I use. Biggest hurtle has been keeping myself CALM! I suffer from depression and anxiety and getting all bent out of shape can cause the spasms to come on. If I do get into a tizzy, I have some eye massage visors that warm and massage my eyes. My eyes are slowly getting better, which is a blessing!