I use Biotrue preservative free drops when my eyes are really dry - I love that they come in a bottle instead of a vial. I have them on subscribe and save to save a bit more money. I use the Systane with preservatives when I've been out in the yard or for a walk and feel like I just need to flush the debris out of my eye - always 3 times a day or less due to the preservatives. My doctor gave me a sample of Refresh but I didn't really notice a difference. I'm tempted to try the equate ones for the savings, but I can buy regular Systane bottles at Sam's so they're already pretty reasonable. However, taking my contacts out and dousing them with contact lens solution (I use Biotrue) is the most effective dry eye relief, so if I'm home and able to do that I always prefer it to using drops. I haven't needed the gel at night in a long time, plus I put restasis in right before bed so I'm often asleep before I'd be able to wait and do a gel drop. Great question and discussion! -Ava, CDE team